Publications

2025

• Écoulements de suspensions fluide-particules dominés par la sédimentation
  
  • Hmamou Ibrahim
  • Lucas Carine
  • Girolami Laurence
  • Delestre Olivier
  • Bondesan Andrea
  • James François
  , 2025.
• Dam-break flow over various obstacles configurations
  
  • Beteille Elisa
  • Larrarte Frederique
  • Boyaval Sebastien
  • Demay Eric
  • Le Minh-Hoang
  Journal of Hydraulic Research, Taylor & Francis, 2025, 63, pp.156-170. Fast floods resulting from the failure of hydraulic structures can be characterized by ‘dam-break’ type waves. They pose catastrophic risks to downstream populations and result in severe structural damage, especially in urban areas. To assess and mitigate these risks, it is essential to forecast the influence of urban forms on flooding severity at a global scale. This paper provides datasets from reduced-scale physical experiments of transient flow through various obstacles configurations. The experiments are conducted in a rectangular horizontal open channel, where flow conditions are achieved by rapidly opening a gate holding a volume of water. To assess the impact of obstacle configurations on flow behaviour, two obstacle sizes are investigated, along with one idealized city layout. The experiments provide complete water hydrographs upstream and downstream of the gate. Additionally, the good performance of the code_saturne computational fluid dynamics (CFD) solver and the volume-of-fluid (VOF) method in numerically simulating the experiments is demonstrated. (10.1080/00221686.2025.2460020)
  DOI : 10.1080/00221686.2025.2460020
• LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer
  
  • Ponchel Théophile
  • Loeffler Emma
  • Ancel Julien
  • Brisebarre Audrey
  • Lalun Nathalie
  • Dalstein Véronique
  • Durlach Anne
  • Deslée Gaëtan
  • Dedieu Stéphane
  • Polette Myriam
  • Nawrocki-Raby Béatrice
  European Journal of Cell Biology, Elsevier, 2025, 104 (1), pp.151475. The tumor suppressor fragile histidine triad (FHIT) is frequently lost in non-small cell lung cancer (NSCLC). We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harboring a FHITlow/pHER2high phenotype are sensitive to anti-HER2 drugs. Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC. Transcriptomic analysis of tumor cells isolated from NSCLC revealed the endocytic receptor low density lipoprotein receptor-related protein 1 (LRP1), a central regulator of membrane trafficking and cell signaling, as a potential player of this signaling. In a cohort of 80 NSCLC assessed by immunohistochemistry, we found a significant association between a low FHIT expression and a high pHER2 and LRP1 expression by tumor cells. Experiments of FHIT silencing showed that FHIT regulated LRP1 expression both at the mRNA and protein levels in lung cell lines. Analyzing the relationship between LRP1 and HER2, we observed that an anti-HER2 targeted therapy reversed LRP1 overexpression induced by FHIT silencing whereas LRP1 silencing did not affect HER2 activity. Studying the functional role of LRP1, we showed that cell proliferation and invasion induced by FHIT silencing were LRP1-dependent. In addition, we found that the induction of vimentin upon FHIT inactivation was counteracted by LRP1 silencing. These results suggest that LRP1 acts downstream of HER2 to induce EMT and tumor progression following FHIT loss. Dual targeting of HER2 and LRP1 might represent a therapeutic strategy to more efficiently inhibit HER2 signaling in FHIT-negative NSCLC. (10.1016/j.ejcb.2024.151475)
  DOI : 10.1016/j.ejcb.2024.151475
• Comment surveiller et prévoir la qualité microbiologique des sites de baignade dans les cours d'eau urbains ? Le site d'étude du bassin de la Villette (Paris)
  
  • Guillot - Le Goff Arthur
  • Angelotti de Ponte Rodrigues Natalia
  • Carmigniani Rémi
  • Vinçon-Leite Brigitte
  TSM. Techniques Sciences Méthodes, Association générale des hygiénistes et techniciens municipaux [1986-2003] - Association scientifique et technique pour l'eau et l'environnement (ASTEE) [2004-....], 2025 (TSM 12/2024), pp.219-228. La baignade dans les cours d’eau urbains bénéficie d’un attrait grandissant. Afin de limiter les risques sanitaires pour les baigneurs, un système d’alerte permet d’anticiper des épisodes de contamination microbiologique et ainsi de mieux gérer l’éventuelle fermeture à la baignade. Cet article présente un système prédictif à court terme (48 heures) développé sur le site d’étude du bassin de La Villette à Paris, où une baignade publique est ouverte en été depuis 2017. Il s’appuie sur la mesure de variables physico-chimiques, hydrauliques et sur la mesure in situ de bactéries indicatrices fécales (BIF) en amont de l’espace de baignade. Le fonctionnement de ce système de suivi et d’alerte est illustré sur l’été 2021. Les données collectées du 1er juin au 31 août 2021 ont révélé un événement de forte contamination microbiologique, ayant entrainé une fermeture du site de baignade, après de fortes précipitations survenues à la mi-juillet. L'intégration de ces mesures à un modèle hydrodynamique, TELEMAC-3D, a permis de simuler le transport des bactéries et leur distribution spatiale. Les mesures, ainsi que la modélisation, ont aussi permis de montrer les effets de la stratification thermique sur la vitesse et la direction de l’écoulement, modifiant alors fortement le temps de transfert des BIF. Les résultats mettent en évidence la capacité de cette approche à anticiper les pics de contamination, fournissant ainsi des informations utiles pour décider de la fermeture et la réouverture des zones de baignade. (10.36904/tsm/202412219)
  DOI : 10.36904/tsm/202412219
• Modelling the hydrodynamic response of a floating offshore wind turbine – a comparative study
  
  • Yu Shimin
  • Ransley Edward
  • Qian Ling
  • Zhou Yang
  • Brown Scott
  • Greaves Deborah
  • Hann Martyn
  • Holcombe Anna
  • Edwards Emma
  • Tosdevin Tom
  • Jagdale Sudhir
  • Li Qian
  • Zhang Yi
  • Zhang Ningbo
  • Yan Shiqiang
  • Ma Qingwei
  • Tagliafierro Bonaventura
  • Capasso Salvatore
  • Martínez-Estévez Iván
  • Göteman Malin
  • Bernhoff Hans
  • Karimirad Madjid
  • Domínguez José
  • Altomare Corrado
  • Viccione Giacomo
  • Crespo Alejandro J.C.
  • Goméz-Gesteira Moncho
  • Eskilsson Claes
  • Fernandez Gael Verao
  • Andersen Jacob
  • Palm Johannes
  • Niosi Francesco
  • Dell'Edera Oronzo
  • Sirigu Massimo
  • Ghigo Alberto
  • Bracco Giovanni
  • Cui Fuyin
  • Chen Shuling
  • Wang Wei
  • Zhuo Yueyue
  • Li Yang
  • Peyrard Christophe
  • Benguigui William
  • Barcet Matthieu
  • Robaux Fabien
  • Benoit Michel
  • Teles Maria
  • Ntouras Dimitris
  • Manolas Dimitris
  • Papadakis George
  • Riziotis Vasilis
  • Zheng Zhiping
  • Lei Weicheng
  • Wang Ruizhi
  • Chen Jikang
  • Shao Yanlin
  • Visbech Jens
  • Bingham Harry
  • Engsig-Karup Allan
  • Zhou Yiming
  • Cai Yefeng
  • Zhao Haisheng
  • Shi Wei
  • Li Xin
  • Zeng Xinmeng
  • Xue Yingjie
  • Zhuang Tiegang
  • Wan Decheng
  • Engel Gaspard
  • Tierno Matthieu
  • Ducrozet Guillaume
  • Bouscasse Benjamin
  • Leroy Vincent
  • Ferrant Pierre
  • Barajas Gabriel
  • Lara Javier
  Applied Ocean Research, Elsevier, 2025, 155, pp.104441. (10.1016/j.apor.2025.104441)
  DOI : 10.1016/j.apor.2025.104441
• Meteorological Conditions Influence the Migration of a Marine Dune Field in the Southern North Sea
  
  • Durand Noémie
  • Tassi Pablo
  • Blanpain Olivier
  • Lefebvre Alice
  Journal of Geophysical Research: Earth Surface, American Geophysical Union/Wiley, 2025, 130 (1). A field of marine dunes has been studied in the Southern Bight of the North Sea. These large dunes, 1–5 m in height and several hundred meters in length, are highly mobile: migration rates of up to 30 m/year have been observed in places. The area is dominated by tides and is characterized by strong currents. Winds are predominantly from the southwest and, to a lesser extent, from the north. A large‐scale 3D numerical model was used to simulate the migration of this dune field over time. It is based on the process‐based openTELEMAC system. The model has been calibrated and validated against in situ bathymetric data and is therefore suited to our objective: to explore the contribution of weather (wind and atmospheric pressure) to the propagation of large marine dunes, in relation to that of tidal currents. To do this, a 4‐month period was simulated, with and without meteorological effects being taken into account in the numerical model. The results highlight the fundamental role of wind conditions in an accurate representation of seabed changes over time. They also show how meteorological events that are different from the prevailing conditions influence the short‐term evolution of the dune field. (10.1029/2024JF007731)
  DOI : 10.1029/2024JF007731
• Flow patterns in shallow rectangular reservoirs with open channel inlet or pipe flow inlet at various depths: An experimental study
  
  • Chagdali El Mehdi
  • El Kadi Abderrezzak Kamal
  • Erpicum Sébastien
  • Goeury Cédric
  • Secher Matthieu
  • Dewals Benjamin
  International Journal of Sediment Research, Elsevier, 2025, 40 (2), pp.209-221. This study experimentally assesses the influence of varying the inlet boundary condition on the flow patterns in rectangular shallow reservoirs. Two types of inlet boundary conditions were compared: a free surface inlet channel, and a pressurized circular inlet jet positioned at three different elevations over the flow depth (centroid of the inlet jet situated at 25%, 50%, or 75% of the flow depth). The outlet boundary condition was a free surface channel in all cases. Twenty-two experiments were done with two distinct reservoir lengths (length-to-width ratios of 1.1 and 2.0) and three hydraulic boundary conditions (Froude numbers of 0.14, 0.16, and 0.21). Velocity fields were measured with Large-Scale Particle Image Velocimetry (LSPIV) at the surface, and with an Acoustic Doppler Velocity Profiler(ADVP) at several cross sections. The flow patterns are greatly influenced by the inlet boundary condition and the reservoir geometry, but to a lesser extent by the hydraulic boundary condition. For an inlet circular jet located near the reservoir bottom, an unstable flow type, changing over time in a chaotic manner, was observed regardless of the reservoir length and of the inlet flow rate. The same type of unstable flow pattern was observed for a relatively long reservoir and the lowest tested flow rate, irrespective of the vertical positioning of the inlet jet. In all other tested configurations, a steady reattached jet was found in the reservoir equipped with a pressurized inlet jet. In addition to providing new knowledge on flow patterns in shallow reservoirs with an inlet jet, the experimental data presented here will prove valuable for evaluating flow computational models. (10.1016/j.ijsrc.2025.01.004)
  DOI : 10.1016/j.ijsrc.2025.01.004
• Usages récréatifs des cours d'eau : activités sportives en eau libre
  
  • Carmigniani Rémi Arthur
  • Guillot - Le Goff Arthur
  • Brigitte Vinçon-Leite
  Transitions. Les nouvelles Annales des Ponts et Chaussées, École des Ponts ParisTech et Presses des Ponts, 2025, L’eau sous contraintes : un objet d’étude à l’intersection de multiples recherches (5), pp.111.
• Faster than real-time, phase-resolving, data-driven model of wave propagation and wave–structure interaction
  
  • Harris Jeffrey
  Applied Ocean Research, Elsevier, 2025, 154, pp.104291. A machine learning time-series prediction approach is proposed for wave propagation and wave load prediction. Under unidirectional wave conditions and variable bathymetry, given a wave gauge upstream, a model is shown to reproduce wave elevation or wave forces downstream under irregular steep and either non-breaking or breaking conditions. Attempts to perform the opposite calculation, predicting upstream conditions from downstream measurements, results in higher error, likely due to information loss under breaking conditions. For choice of machine learning approach, comparisons show that the Time-series Dense Encoder (TiDE) approach results in a good balance between model complexity, stability, computational time, and error. Over a flat bottom, time-series of wave elevation can be predicted up to 10 wavelengths away, though with a degraded accuracy compared to shorter distances. Similar results are shown for time-series of forces on a vertical cylinder, showing better results than a simple Morison approach, as used in engineering tools such as OpenFAST, but with a similarly fast computational time. Generalizations show that training on irregular wave data permit extrapolations to periodic wave cases. Finally, the same method also is also demonstrated at field-scale, comparing results between two offshore buoys. (10.1016/j.apor.2024.104291)
  DOI : 10.1016/j.apor.2024.104291
• Modeling Solute Transport in Rivers: Analytical and Numerical Solutions
  
  • Bey-Zekkoub Mohamed
  • Tassi Pablo
  • Lucas Carine
  • Chhim Norinda
  Environmental Modelling and Software, Elsevier, 2025, pp.106580. This study presents a novel analytical framework for modeling one-dimensio- nal solute transport in rivers, integrating advection, rate-limited adsorption on suspended sediments, and first-order degradation. Analytical solutions are used to validate the numerical scheme’s accuracy under idealized conditions, tested for instantaneous and continuous pollutant discharges. The research importantly investigates short-term solute accumulation in riverbeds, a crit- ical yet understudied process that affects sediment transport and pollutant fate. Applicable to a wide range of contaminants (e.g., nutrients, pesti- cides), the framework aids water quality assessment, pollution control, and risk mitigation. Implemented in the open-source SWASHES library, these solutions provide practical tools for decision-support systems and serve as reliable benchmarks to validate numerical models. By addressing transient and persistent pollutant scenarios, this work enhances predictive capabili- ties for environmental management. The approach bridges analytical and numerical methods, offering a robust foundation for simulating solute trans- port across industrial and ecological contexts, advancing sustainable water resource management. (10.1016/j.envsoft.2025.106580)
  DOI : 10.1016/j.envsoft.2025.106580
• Capteurs en ligne et modèles prédictifs : des plateformes numériques pour surveiller la qualité microbiologique des milieux aquatiques urbains
  
  • Guillot - Le Goff Arthur
  • Carmigniani Rémi Arthur
  • Brigitte Vinçon-Leite
  Transitions. Les nouvelles Annales des Ponts et Chaussées, École des Ponts ParisTech et Presses des Ponts, 2025, L’eau sous contraintes : un objet d’étude à l’intersection de multiples recherches (5), pp.37.
• A comparison of eight weakly dispersive Boussinesq-type models for non-breaking long-wave propagation in variable water depth
  
  • Coulaud Guillaume
  • Teles Maria
  • Benoit Michel
  Coastal Engineering, Elsevier, 2025, 195, pp.104645. Weakly dispersive Boussinesq-type models are extensively used to model long-wave propagation in coastal areas and their interaction with coastal infrastructures. Many equations falling in this category have been formulated during the last decades, but few detailed comparisons between them can be found in the literature. In this work, we investigate theoretically and with computational experiments eight variants of the most popular models used by the coastal engineering community. Both weakly nonlinear and fully nonlinear models are considered, hoping to understand better when the additional complexity of the latter class of models is necessary or justified. We provide an overview and discuss the properties of these models, including the linear dispersion relation in uniform water depth, the second-order nonlinear coupling coefficient, the shoaling gradient, and the sensitivity to wave trough instabilities. The models are then numerically discretised using the same general strategy in a single numerical code, using fourth-order methods for time and space discretisation. Their capacity to simulate coastal wave propagation and their transformation when approaching the shore is assessed on three challenging one-dimensional benchmarks. It appears that fully nonlinear models are more consistent than their weakly nonlinear counterparts, which can occasionally perform better but show different behaviours depending on the case. (10.1016/j.coastaleng.2024.104645)
  DOI : 10.1016/j.coastaleng.2024.104645
• Reducing the Dimension of Infered Time-Varying Boundary conditions to Improve Water Levels Prediction in the Gironde Estuary using Telemac2D and an Ensemble Kalman Filter Research Article
  
  • Laborie Vanessya
  • Ricci Sophie
  • Goutal Nicole
  Environmental Science and Climate Research, OPAST Publishers, 2025, 3 (1). In order to better predict high water levels and floods in the Gironde estuary, a Telemac 2D numerical model is combined with a stochastic Ensemble Kalman Filter (EnKF). The hydrodynamic model calculates water depths and velocity fields at each node of an unstructured mesh. The EnKF corrects the inputs of the model, i.e both scalar parameters and timevarying forcings, as it assimilates in situ water levels observations. Upstream, the model fluvial boundaries are respectively located at La R´eole and Pessac on the Garonne and Dordogne rivers. The maritime boundary is 32 km off the mouth of the Gironde estuary, located at Le Verdon. It is assumed that the uncertainty in time-varying boundary conditions is well approximated by a Gaussian Process (GP) characterized by its autocorrelation function and associated correlation time scale. The coefficients of the truncated Karhunen-Lo`eve decomposition of this GP are further considered in the EnKF control vector, together with the area-prescribed friction coefficients and the wind influence coefficient. The data assimilation strategy performance was assessed with twin-and real experiments which respectively use synthetic water levels observations and in situ water levels measurements. Twin experiments showed that the proposed methodology succeeds in identifying time varying friction, as well as reconstructing the boundary conditions even though the identification of the Karhunen-Lo`eve coefficients for the time-dependent boundary conditions suffers equifinality. Indeed, the results show the proper reconstruction of the maritime forcing and consequently the expected water levels in the estuary, improving water levels prediction in the Gironde Estuary. However, difficulties in estimating the friction parameter in the confluence zone, where the flows are the result of non-linear physical processes, were highlighted. Real experiments showed that, in spite of these limitations, water levels are significantly improved by assimilating in situ observations, as absolute errors remain smaller than 13 cm at high tides (HT) along the estuary, except in the upstream reaches of the Garonne and Dordogne rivers where the model refinement should be improved. (10.33140/ESCR.03.01.08)
  DOI : 10.33140/ESCR.03.01.08